Authors' Note: A course of high-dose synthetic corticosteroids, e.g. dexamethasone, may be used to help bring under control a severe exacerbation of a chronic illness, e.g. asthma, inflammatory diseases, or an initial presentation, e.g. anaphylaxis, septic shock or brain swelling. Owing to the common side-effect of drug-induced euphoria/mania and other psychiatric issues, doctors attempt to taper the high doses as soon as possible.
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