Authors' Note: A deficiency of the pituitary hormone ADH (anti-diuretic hormone, also known as vasopressin), is the most common cause of a spontaneous development of polyuria due to diabetes insipidus. This disorder, characterized by passing of large volumes of urine, is partly compensated by increased thirst. A lack of sugar in the urine despite its large volume would exclude glycosuria due to diabetes mellitus. Radiographic tests done in this situation would definitely include evaluation of the skull base, as a tumour involving the posterior portion of the pituitary gland is a common cause.
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