MAY 17, to clot, or not: coagulation cascade (hemophilia)

Authors' Note: The most common complication of internal bleeding in hemophilic patients is hemarthrosis, bleeding into joints, that may be unprovoked, yet result in significant disability.

Earlier versions of replacement therapy to provide for missing blood proteins with human blood-bank products has been discussed previously. Current treatment involves a genetically engineered  material derived from hamster cells, superior in not provoking antibodies that limit its effectiveness.  

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